Publié le 2017/02/13
Telomeres progressively shorten with increasing age as a consequence of cumulative cycles of cell division that are required for tissue repair and regeneration. This occurs both in differentiated cells as well as in stem cells. Telomere shortening has been demonstrated to impair the ability of stem cells to regenerate tissues when needed. Animal studies have shown that an accumulation of critically short telomeres causes more rapid aging. Interventions that decrease the rate of telomere shortening with age, such as enhancing telomerase, can delay aging and increase longevity. Thus, therapeutic strategies based on telomerase activation are envisioned as potentially important for intervening in agerelated problems.